ESR10 Project
Immobilization of NHC’s ligands in Janus Dendrimers. Catalysis in green solvents e of the base
Recruting institution: UW
Diploma-delivering institutions: UW, UAB
Thesis co-directors: Karol Grela (UW, Warsaw, PL), Rosa Maria Sebastián (UAB, Barcelona, ES)
Secondment host: Henkel KGaA (ES)
Academic secondment: LCC (Toulouse, France)
Objectives
To prepare phosphorus Janus dendrimers[1] as support for NHC-based catalysts for metathesis reactions in different media.[2,3] The incorporation of polyoxyethylenated chains in the macromolecules will provide water solubility, and polyfluorinated chains will allow catalysis in supercritical CO2, enabling the catalysis to be performed in green solvents.[4] Several generations of dendrimers will be prepared and the dendritic effect on the activity and selectivity of catalytic moieties will be analyzed.
[1] A. M. Caminade, C. O. Turrin, R. Laurent, A. Ouali, B. Delavaux-Nicot in Dendrimers: Towards Catalytic, Material and Biomedical Uses, Wiley-VCH, Chistester, 2011.
[2] K. Skowerski, J. Białecki, S. J. Czarnocki, K. Żukowska, K. Grela; Beilstein J. Org. Chem. 2016, 12, 5–15.
[3] G. Szczepaniak, K. Kosiński, K. Grela Green Chem.2014, 16, 4474-4492.
[4] Y. Feng, Y.-M. He, L.-W. Zhao, Y.-Y. Huang, Q.-H. Fan Org. Lett., 2007, 9, 2261–2264.
Expected Results
At least 10 new families of Janus dendrimers (monodisperse polymers) will be obtained, of 3 different generations for each, combining at least 5 newly obtained NHCs, and moieties that will allow their solubility to be modulated mainly in green solvents (water and CO2). Positive dendritic effect are expected when working with different generations. The recovering and reuse of the new macromolecular catalysts at the minimum 10-20 catalytic cycles will improve the TON and TOF in comparison to parental complexes.
Joel Cejas Sánchez
PhD student - ESR10
My name is Joel Cejas Sánchez and I am a graduate in Chemistry from Barcelona. I obtained my Bachelor’s degree at Universitat Autònoma de Barcelona in 2019 with mention in biological chemistry, and I am currently pursuing a MSc in Industrial Chemistry and Advanced Chemical Research in the same institution. My investigation projects these preceding years have been focused in the fields of bioanalytical chemistry, polymers and materials science.
From October I will be enrolled in ESR10 Project supervised by Prof. Grela (University of Warsaw) and Dr. Sebastián (Universitat Autònoma de Barcelona) working in the immobilisation of N-Heterocyclic Carbene ligands in Janus dendrimers for the catalysis of olefin metathesis reactions in green solvents.